Description

(2S,3S)-3-Methyl-2-[2-({[2-(Trimethylsilyl)Ethoxy]Carbonyl}Amino)Acetamido]Pentanoic Acid is a sophisticated, non-natural amino acid derivative featuring a silyl-protected carbamate (Teoc) group, making it a critical building block for advanced peptide synthesis and medicinal chemistry. This compound is engineered to provide superior control over stereochemistry and side-chain functionality, enabling the development of complex, bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutics, including peptide-based drugs and protease inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based pharmaceuticals and protease inhibitors.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected amino acid building block, where the Teoc group offers orthogonal protection strategies compatible with Fmoc/t-Bu chemistry.
• Medicinal Chemistry & Drug Discovery: Used to introduce specific stereochemical and structural motifs into lead compounds to optimize binding affinity, selectivity, and metabolic stability.
• Bioconjugation & Chemical Biology: Employed in the synthesis of peptide probes, tags, and linkers for studying protein-protein interactions and cellular processes.
• Custom Peptide Services: A high-value raw material for CROs and CDMOs offering custom peptide synthesis for academic and industrial clients.
• Ligand Development: Useful in creating specialized ligands for catalysis or as components of metal-organic frameworks (MOFs) with chiral recognition properties.

Basic Information

Product Name	(2S,3S)-3-Methyl-2-[2-({[2-(Trimethylsilyl)Ethoxy]Carbonyl}Amino)Acetamido]Pentanoic Acid
CAS No.	863658-70-2
Molecular Formula	C14H28N2O5Si
Molecular Weight	332.47 g/mol
Synonyms	Teoc-DL-3-Methylnorvaline; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methyl-L-norvaline; Fmoc-3-methyl-L-norvaline; (2S,3S)-2-[(2-{[(2-Trimethylsilylethoxy)carbonyl]amino}acetyl)amino]-3-methylpentanoic acid; 3-Methylnorvaline derivative; Teoc-protected amino acid; CAS 863658-70-2
EINECS	Contact for details

Quality Control

Our production of (2S,3S)-3-Methyl-2-[2-({[2-(Trimethylsilyl)Ethoxy]Carbonyl}Amino)Acetamido]Pentanoic Acid adheres to stringent quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot is fully characterized and tested against rigorous in-house specifications, which are aligned with the standards expected for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.