Description

Pep-1-Cysteamide CAS NO 863608-35-9 is a specialized cysteine derivative peptide intermediate designed for advanced bioconjugation and pharmaceutical research. This compound is critical for the synthesis of peptide-based therapeutics and diagnostic agents, offering a reactive thiol group for site-specific modifications. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of targeted drug delivery systems, antibody-drug conjugates (ADCs), and novel biochemical probes.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serves as a key building block for constructing cleavable or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Peptide Therapeutics Synthesis: Used as a modified cysteine residue in solid-phase peptide synthesis (SPPS) to introduce functional handles or stability-enhancing motifs.
• Bioconjugation and Protein Labeling: Enables site-specific attachment of fluorophores, biotin, polyethylene glycol (PEG), or other molecules to proteins and peptides via thiol-maleimide or disulfide chemistry.
• Prodrug Development: Incorporated into prodrug constructs where the amide bond can be enzymatically cleaved to release an active pharmaceutical ingredient (API).
• Chemical Biology Research: Acts as a tool compound for studying protein-protein interactions, enzyme mechanisms, and cellular uptake pathways.
• Diagnostic Reagent Formulation: Utilized in the development of contrast agents or labeled probes for molecular imaging applications.

Basic Information

Product Name	Pep-1-Cysteamide
CAS No.	863608-35-9
Molecular Formula	C9H16N4O3S
Molecular Weight	260.31 g/mol
Synonyms	Pep-1-Cysteamide; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-trityl-L-cysteinamide; Fmoc-Cys(Trt)-NH2; Fmoc-Cysteine(Trt)-amide; Fmoc-L-Cysteine(Trt) amide; N-α-Fmoc-S-trityl-L-cysteinamide; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-tritylsulfanyl-propanamide; L-Cysteine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-S-(triphenylmethyl)-, amide
EINECS	Contact for details

Quality Control

Our Pep-1-Cysteamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral purity analysis to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage under an inert atmosphere, please contact our technical team for specific recommendations. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (L-Isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.