Description

1-Iodo-4-(1,1,2,2-Tetrafluoroethoxy)Benzene, also known as 4-Iodophenyl 1,1,2,2-Tetrafluoroethyl Ether, is a high-value, fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, combining an iodine substituent with a tetrafluoroethoxy side chain, makes it a versatile precursor for constructing complex molecules through cross-coupling reactions. This compound is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluorinated aromatic motifs which can enhance metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the fluorinated ether group can improve lipophilicity and target binding.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in advanced electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The iodine atom acts as an excellent handle for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings to create complex biaryl and conjugated systems.
• Polymer & Specialty Chemicals: Employed in the synthesis of fluorinated monomers and polymers for high-performance materials with unique chemical resistance and surface properties.
• R&D & Process Chemistry: Essential for medicinal chemistry and process development in both academic and industrial research laboratories exploring new chemical entities.

Basic Information

Product Name	1-Iodo-4-(1,1,2,2-Tetrafluoroethoxy)Benzene
CAS No.	863323-03-9
Molecular Formula	C8H5F4IO
Molecular Weight	320.03 g/mol
Synonyms	4-Iodophenyl 1,1,2,2-Tetrafluoroethyl Ether; 4-(1,1,2,2-Tetrafluoroethoxy)Iodobenzene; 1-Iodo-4-(2,2,2-trifluoroethoxy)benzene (related); p-Iodophenyl Tetrafluoroethyl Ether; Benzene, 1-iodo-4-(1,1,2,2-tetrafluoroethoxy)-; 4-Iodo-1-(1,1,2,2-tetrafluoroethoxy)benzene; 863323-03-9; Tetrafluoroethoxyiodobenzene
EINECS	Contact for details

Quality Control

Our 1-Iodo-4-(1,1,2,2-Tetrafluoroethoxy)Benzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems support the stringent requirements of pharmaceutical and advanced material research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use. Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.