Description

1-Bromo-4-Chloro-2-Nitro-5-(Trifluoromethyl)-Benzene is a high-value, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring bromine, chlorine, nitro, and trifluoromethyl substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated, nitro-substituted, or trifluoromethylated aromatic cores.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the specific substitution pattern can enhance biological activity and environmental stability.
• Material Science Research: Acts as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine and chlorine atoms provide orthogonal reactivity for sequential palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to build complex biaryl systems.
• Nucleophilic Aromatic Substitution: The activated nitro group adjacent to halogens facilitates nucleophilic substitution reactions, enabling the introduction of amines, alkoxides, and other nucleophiles.
• Fluorine Chemistry Building Block: The stable trifluoromethyl group is valuable for introducing lipophilicity and metabolic stability into target molecules, a common strategy in medicinal chemistry.

Basic Information

Item	Detail
Product Name	1-Bromo-4-Chloro-2-Nitro-5-(Trifluoromethyl)-Benzene
CAS No.	863111-47-1
Molecular Formula	C7H2BrClF3NO2
Molecular Weight	304.45 g/mol
Synonyms	4-Bromo-1-Chloro-2-Nitro-5-(Trifluoromethyl)benzene; 2-Nitro-4-Bromo-1-Chloro-5-(Trifluoromethyl)benzene; 5-(Trifluoromethyl)-2-Nitro-1-Chloro-4-Bromobenzene; 1-Chloro-4-Bromo-2-Nitro-5-(Trifluoromethyl)benzene; Benzene, 1-bromo-4-chloro-2-nitro-5-(trifluoromethyl)-; BCPNTFB
EINECS	Contact for details

Quality Control

Our production of 1-Bromo-4-Chloro-2-Nitro-5-(Trifluoromethyl)-Benzene adheres to stringent in-process controls and final release specifications to ensure batch-to-batch consistency and high purity. Every lot is characterized by modern analytical techniques including HPLC, GC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing all relevant specifications are provided with each shipment. We operate under a quality management system aligned with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound should be stored separately from strong bases and reducing agents.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (HPLC/GC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.