Description

Boc-D-Hyp-Otbu is a protected amino acid derivative, specifically the tert-butyl ester of N-(tert-butoxycarbonyl)-D-hydroxyproline. This high-purity chiral building block is essential for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors and bioactive peptides.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Solid-Phase Peptide Synthesis (SPPS): Used for the controlled incorporation of D-hydroxyproline residues into peptide chains, enabling the study of structure-activity relationships.
• Protease Inhibitor Design: Serves as a critical component in the synthesis of inhibitors targeting specific enzymes like collagenases or prolyl hydroxylases.
• Bioconjugation and Labeling: The protected functional groups allow for selective deprotection and subsequent conjugation with labels, tags, or other biomolecules.
• Academic and R&D Laboratories: Employed in medicinal chemistry and chemical biology research for exploring new peptide architectures and functions.
• Production of Reference Standards: Used to prepare high-purity analytical standards for quality control in pharmaceutical manufacturing.

Basic Information

Product Name	Boc-D-Hyp-Otbu
CAS No.	862996-27-8
Molecular Formula	C14H25NO5
Molecular Weight	287.35 g/mol
Synonyms	(2R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-4-hydroxypyrrolidine-2-carboxylic acid tert-butyl ester; tert-Butyl (2R)-4-hydroxy-1-{[(2-methylpropan-2-yl)oxy]carbonyl}pyrrolidine-2-carboxylate; N-Boc-D-4-hydroxyproline tert-butyl ester; Boc-D-hydroxyproline-OtBu; Boc-D-4-Hyp-OtBu; (R)-1-Boc-4-hydroxyproline tert-butyl ester; N-tert-Butoxycarbonyl-D-4-hydroxyproline tert-butyl ester
EINECS	Contact for details

Quality Control

Our Boc-D-Hyp-Otbu is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.