Description

N,n-Bis[2-(1,1-Dimethylethoxy)-2-Oxoethyl]-L-Glutamic Acid 1-(1,1-Dimethylethyl) Ester is a sophisticated, multi-protected derivative of L-glutamic acid, designed for advanced synthetic applications where precise control over reactivity is paramount. This compound is a critical building block in the synthesis of complex peptides and other bioactive molecules, offering chemoselective deprotection pathways. It is essential for research and development laboratories in the pharmaceutical and biotechnology sectors focused on novel drug discovery and process chemistry. The high-purity grade ensures reliable performance in sensitive synthetic sequences.

Application

• Pharmaceutical Intermediate: Serves as a key protected amino acid derivative in the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Drug Discovery Research: Used in medicinal chemistry for constructing novel molecular scaffolds and exploring structure-activity relationships (SAR).
• Process Chemistry Development: Employed in the development and scale-up of synthetic routes for active pharmaceutical ingredients (APIs), leveraging its orthogonal protecting groups.
• Bioconjugation Chemistry: Acts as a linker or spacer molecule in the design of antibody-drug conjugates (ADCs) and other targeted therapeutic agents.
• Biochemical Research: Utilized in the study of glutamate receptor ligands and the synthesis of labeled compounds for metabolic studies.
• Custom Synthesis: A foundational reagent for contract research and manufacturing organizations (CROs/CMOs) producing specialized fine chemicals for clients.

Basic Information

Item	Details
Product Name	N,n-Bis[2-(1,1-Dimethylethoxy)-2-Oxoethyl]-L-Glutamic Acid 1-(1,1-Dimethylethyl) Ester
CAS No.	862778-55-0
Molecular Formula	C21H37NO9
Molecular Weight	447.52 g/mol
Synonyms	L-Glutamic acid, N,N-bis[2-[(1,1-dimethylethoxy)carbonyl]ethyl]-, 1-(1,1-dimethylethyl) ester; tert-Butyl N,N-bis[2-(tert-butoxy)-2-oxoethyl]-L-glutamate; Boc-Glu(OtBu)-OtBu (protected form); Fmoc-Glu(OtBu)-OtBu precursor; N,N-Di-Boc-L-glutamic acid tert-butyl ester; Protected L-glutamic acid tert-butyl ester; Glutamic acid derivative with tert-butyl and tert-butoxycarbonyl protections
EINECS	Contact for details

Quality Control

Our N,n-Bis[2-(1,1-Dimethylethoxy)-2-Oxoethyl]-L-Glutamic Acid 1-(1,1-Dimethylethyl) Ester is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and NMR for structural verification. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.