Description

Cyclo(-Arg-Gly-Asp-D-Phe-Cys) CAS NO 862772-11-0 is a synthetic, cyclic pentapeptide featuring the Arg-Gly-Asp (RGD) motif, a critical sequence for cell adhesion. This compound matters as a potent and selective inhibitor of integrin receptors, specifically targeting αvβ3 and αvβ5 integrins involved in cell signaling and migration. It is primarily needed by researchers in pharmaceutical development and biotechnology for applications in cancer research, angiogenesis studies, and as a biochemical tool for investigating cell-matrix interactions.

Application

• Biomedical Research: Used as a selective antagonist to study the role of αvβ3 and αvβ5 integrins in cellular processes like angiogenesis, tumor metastasis, and bone resorption.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the development of novel anti-cancer and anti-angiogenic therapeutics.
• Cell Biology Studies: Employed to inhibit cell adhesion and migration in vitro, facilitating research on extracellular matrix interactions and signaling pathways.
• Biomaterial & Tissue Engineering: Used to functionalize surfaces to modulate cell attachment and proliferation for scaffold development and regenerative medicine applications.
• Diagnostic Tool Development: Potential use in developing imaging agents or assays targeting integrin expression in pathological tissues.

Basic Information

Product Name	Cyclo(-Arg-Gly-Asp-D-Phe-Cys)
CAS No.	862772-11-0
Molecular Formula	C27H40N10O7S
Molecular Weight	648.75 g/mol
Synonyms	c(RGDfC); Cyclo(Arg-Gly-Asp-D-Phe-Cys); Cilengitide intermediate; Cyclo(RGDfC); cRGDfC peptide; Cyclo(-L-arginyl-glycyl-L-α-aspartyl-D-phenylalanyl-L-cysteine); Integrin αvβ3 antagonist (cyclic RGD peptide); Cyclopentapeptide RGDfC
EINECS	Contact for details

Quality Control

Our Cyclo(-Arg-Gly-Asp-D-Phe-Cys) is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and MS for identity confirmation, to ensure compliance with high-purity standards for research use. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.