Description

4-Fluoro-2-(Methylthio)Phenylboronic Acid is a versatile and high-value organoboron building block essential for modern synthetic chemistry. Its unique structure, featuring both fluorine and methylthio substituents, makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought after by R&D chemists and process development scientists working on new active ingredients, particularly in the areas of medicinal chemistry and crop protection.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine and sulfur-containing motifs enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Process Chemistry & Scale-up: Utilized in route scouting and optimization for the commercial-scale production of fine chemicals and active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4-Fluoro-2-(Methylthio)Phenylboronic Acid
CAS No.	861931-38-6
Molecular Formula	C7H8BFO2S
Molecular Weight	185.99 g/mol
Synonyms	(4-Fluoro-2-(methylthio)phenyl)boronic acid; 2-(Methylthio)-4-fluorobenzeneboronic acid; 4-Fluoro-2-methylsulfanylbenzeneboronic acid; 4-Fluoro-2-(methylmercapto)benzeneboronic acid; B-[4-Fluoro-2-(methylthio)phenyl]boronic acid; 861931-38-6; 4-Fluoro-2-methylthiobenzeneboronic Acid
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-2-(Methylthio)Phenylboronic Acid is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and other relevant techniques is supplied with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.