Description

(S)-3-Chloro-2-(2,4-Difluorophenyl)-2-((Trimethylsilyl)Oxy)Propanenitrile is a high-value, optically active synthetic intermediate characterized by its chiral center and protective silyl ether group. This compound matters for its critical role in the enantioselective synthesis of complex molecules, particularly in the pharmaceutical sector where stereochemical purity is paramount. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of antifungal agents, CNS-active compounds, and other therapeutic molecules requiring high enantiomeric purity.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where the specific stereochemistry influences biological activity.
• Asymmetric Catalysis Research: Serves as a substrate or ligand precursor in the development of new catalytic systems for stereoselective transformations.
• Fine Chemical Production: Employed in multi-step organic syntheses to introduce the difluorophenyl moiety and chiral chloro-nitrile functionality into target molecules.
• Process Chemistry Development: Utilized in scaling up synthetic routes from laboratory to pilot plant and commercial production for API manufacturing.
• Academic & Institutional Research: A valuable reagent for methodological studies in organic chemistry, particularly in fluorination and silylation chemistry.

Basic Information

Product Name	(S)-3-Chloro-2-(2,4-Difluorophenyl)-2-((Trimethylsilyl)Oxy)Propanenitrile
CAS No.	861718-83-4
Molecular Formula	C12H12ClF2NOSi
Molecular Weight	287.77 g/mol
Synonyms	(S)-3-Chloro-2-(2,4-difluorophenyl)-2-[(trimethylsilyl)oxy]propanenitrile; (S)-2-(2,4-Difluorophenyl)-3-chloro-2-(trimethylsiloxy)propionitrile; (S)-α-Chloro-2,4-difluorobenzyl cyanide trimethylsilyl ether; Propanenitrile, 3-chloro-2-(2,4-difluorophenyl)-2-[(trimethylsilyl)oxy]-, (2S)-; TMS-protected (S)-2-Chloro-2-(2,4-difluorophenyl)acetonitrile cyanohydrin
EINECS	Contact for details

Quality Control

Our (S)-3-Chloro-2-(2,4-Difluorophenyl)-2-((Trimethylsilyl)Oxy)Propanenitrile is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, essential for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.