Description

Oxazole, 2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4-(1-Methylethyl)-5,5-Diphenyl-, (4S)- is a sophisticated chiral organophosphorus-oxazole hybrid ligand. This compound is of significant value in asymmetric catalysis, where it serves as a highly effective ligand for transition metals, enabling the synthesis of enantiomerically pure compounds. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel synthetic methodologies and active pharmaceutical ingredients (APIs).

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediates.
• Catalyst component in enantioselective C-C and C-X bond-forming reactions.
• Key reagent in academic and industrial research for developing new catalytic systems.
• Used in the synthesis of complex natural products and fine chemicals requiring high stereochemical control.
• Potential application in material science for creating chiral molecular frameworks.

Basic Information

Product Name	Oxazole, 2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4-(1-Methylethyl)-5,5-Diphenyl-, (4S)-
CAS No.	861718-64-1
Molecular Formula	C38H34NOP
Molecular Weight	551.66 g/mol
Synonyms	(4S)-2-[2-(Diphenylphosphino)phenyl]-4-(1-methylethyl)-5,5-diphenyl-4,5-dihydrooxazole; (S)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazole; (S)-iPr-PHOX; (S)-4-Isopropyl-5,5-diphenyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole; PHOX Ligand (iPr variant); Chiral Dihydrooxazole Phosphine Ligand; Asymmetric Hydrogenation Ligand; Josiphos-type ligand analog.
EINECS	Contact for details

Quality Control

Our production of this high-value chiral ligand adheres to strict quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Every lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm chemical identity, high purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere such as argon or nitrogen to ensure long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.