Description

Benzamide, n-(Methylnitrosoamino)- (1Ci) is a specialized isotopically labeled compound, specifically a carbon-13 labeled nitrosamine derivative. This high-purity chemical is critical for advanced analytical and research applications where precise molecular tracking is required. It serves as an essential reference standard and precursor for researchers and quality control laboratories in the pharmaceutical, toxicology, and environmental analysis sectors, enabling accurate detection and quantification studies.

Application

• Analytical Reference Standard: Used as a certified internal standard for the precise quantification of nitrosamine impurities in active pharmaceutical ingredients (APIs) and finished drug products via LC-MS/MS and GC-MS.
• Metabolic Pathway Tracing: Employed in pharmacokinetic and metabolic studies to trace the biotransformation and distribution of nitrosamine compounds using isotope-ratio mass spectrometry.
• Environmental Analysis: Serves as a spike or recovery standard in the analysis of nitrosamine contaminants in water, soil, and food samples for regulatory compliance testing.
• Toxicology Research: Facilitates mechanistic studies on the formation, reactivity, and genotoxic effects of N-nitrosamines in biological systems.
• Method Development & Validation: Critical for developing, optimizing, and validating highly sensitive analytical methods for nitrosamine detection in compliance with ICH M7 and regulatory guidelines.
• Stable Isotope Labeling: Acts as a building block for the synthesis of more complex isotopically labeled molecules for use in advanced mass spectrometry applications.

Basic Information

Product Name	Benzamide, n-(Methylnitrosoamino)- (1Ci)
CAS No.	861377-84-6
Molecular Formula	C8H913CN2O2
Molecular Weight	~180.6 g/mol (for 13C labeled)
Synonyms	N-Nitroso-N-methylbenzamide-13C; N-Methyl-N-nitrosobenzamide-13C; N-Methyl-N-nitrosobenzenecarboxamide-13C; NMBA-13C; Benzamide, N-methyl-N-nitroso- (13C); [13C]-N-Nitroso-N-methylbenzamide; Stable Isotope Labeled N-Nitroso-N-methylbenzamide
EINECS	Contact for details

Quality Control

Every batch of Benzamide, n-(Methylnitrosoamino)- (1Ci) is manufactured and analyzed under strict quality management systems. The product undergoes rigorous testing to ensure high chemical purity, isotopic enrichment, and structural identity, meeting the exacting standards required for analytical and research use. Comprehensive Certificates of Analysis (COA) are provided, detailing results for assay, isotopic purity, radiochemical purity (if applicable), and identification by spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. For long-term storage, keep the container in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (13C)	≥ 99 atom % 13C
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.