Description

(E)-2-[(4-Methylphenyl)Sulfonyl]-3-[3-(2-Pyrimidinyloxy)Phenyl]-2-Propenenitrile is a high-purity, advanced pharmaceutical intermediate characterized by its specific sulfonyl and pyrimidinyloxy functional groups. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel therapeutic agents. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Key intermediate in the research and synthesis of novel pharmaceutical compounds, particularly kinase inhibitors.
• Building block for the development of agrochemicals, including herbicides and fungicides.
• Used in academic and industrial research for studying structure-activity relationships (SAR) in medicinal chemistry.
• Precursor in the synthesis of specialized fine chemicals and functional materials.
• Valuable reagent for organic synthesis laboratories focusing on cross-coupling and other advanced reactions.

Basic Information

Product Name	(E)-2-[(4-Methylphenyl)Sulfonyl]-3-[3-(2-Pyrimidinyloxy)Phenyl]-2-Propenenitrile
CAS No.	861210-23-3
Molecular Formula	C20H15N3O3S
Molecular Weight	377.42 g/mol
Synonyms	(E)-2-(p-Tolylsulfonyl)-3-[3-(pyrimidin-2-yloxy)phenyl]acrylonitrile; 2-[(4-Methylphenyl)sulfonyl]-3-[3-(2-pyrimidinyloxy)phenyl]-2-propenenitrile; 2-(4-Methylbenzenesulfonyl)-3-[3-(pyrimidin-2-yloxy)phenyl]acrylonitrile; 861210-23-3; (E)-2-(Tosyl)-3-(3-(pyrimidin-2-yloxy)phenyl)acrylonitrile; Propenenitrile, 2-[(4-methylphenyl)sulfonyl]-3-[3-(2-pyrimidinyloxy)phenyl]-, (2E)-; (E)-3-(3-(Pyrimidin-2-yloxy)phenyl)-2-tosylacrylonitrile
EINECS	Contact for details

Quality Control

Our (E)-2-[(4-Methylphenyl)Sulfonyl]-3-[3-(2-Pyrimidinyloxy)Phenyl]-2-Propenenitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.