Description

(E)-4-(1,3-Benzoxazol-6-Ylamino)-4-Oxo-2-Butenoic Acid is a high-purity, specialized organic compound featuring a benzoxazole core linked to an α,β-unsaturated carboxylic acid moiety via an amide bond. This unique structure makes it a valuable advanced pharmaceutical intermediate and a versatile building block for medicinal chemistry research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel drug candidates, particularly those targeting kinase inhibition and other therapeutic pathways.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new drug candidates.
• Chemical Biology Probe Synthesis: Serves as a precursor for creating labeled compounds or probes to study biological pathways and target engagement.
• Organic Synthesis: Utilized as a versatile scaffold for constructing complex heterocyclic compounds due to its reactive carboxylic acid and amide functionalities.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and process development for client projects.

Basic Information

Product Name	(E)-4-(1,3-Benzoxazol-6-Ylamino)-4-Oxo-2-Butenoic Acid
CAS No.	860785-22-4
Molecular Formula	C11H8N2O4
Molecular Weight	232.19 g/mol
Synonyms	(E)-4-((1,3-Benzoxazol-6-yl)amino)-4-oxobut-2-enoic acid; 4-[(1,3-Benzoxazol-6-yl)amino]-4-oxo-2-butenoic acid, (E)-; (E)-4-Oxo-4-((1,3-benzoxazol-6-yl)amino)but-2-enoic acid; 860785-22-4; But-2-enoic acid, 4-[(1,3-benzoxazol-6-yl)amino]-4-oxo-, (2E)-; (E)-4-(Benzoxazol-6-ylamino)-4-oxobut-2-enoic acid
EINECS	Contact for details

Quality Control

Our (E)-4-(1,3-Benzoxazol-6-Ylamino)-4-Oxo-2-Butenoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and physical characteristics. Our quality commitment supports applications in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 98.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.