Description

Boronic Acid, B-(4-Fluoro-2-Nitrophenyl)- is a high-purity, functionalized boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its unique molecular structure, which combines a boronic acid moiety with electron-withdrawing nitro and fluoro substituents, making it an essential reagent for Suzuki-Miyaura cross-coupling reactions. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those requiring biaryl linkages formed via palladium-catalyzed cross-coupling.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that incorporate fluorinated aromatic systems for enhanced bioactivity and stability.
• Material Science: Employed in the creation of organic electronic materials, such as polymers and small molecules for OLEDs or OFETs, where the nitro and fluoro groups tune electronic properties.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes and inhibitors that target specific proteins or enzymes.
• Ligand Synthesis: Serves as a starting material for synthesizing specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Academic & Process R&D: A valuable reagent for methodological studies in organic synthesis and for scaling up novel coupling methodologies.

Basic Information

Product Name	Boronic Acid, B-(4-Fluoro-2-Nitrophenyl)-
CAS No.	860034-00-0
Molecular Formula	C6H5BFNO4
Molecular Weight	184.92 g/mol
Synonyms	(4-Fluoro-2-nitrophenyl)boronic acid; 4-Fluoro-2-nitrophenylboronic acid; 2-Nitro-4-fluorophenylboronic acid; B-(4-Fluoro-2-nitrophenyl)boronic acid; 4-Fluoro-2-nitrobenzeneboronic acid; (4-Fluoro-2-nitrobenzene)boronic acid; 860034-00-0; 4-F-2-NO2-PhB(OH)2
EINECS	Contact for details

Quality Control

Our Boronic Acid, B-(4-Fluoro-2-Nitrophenyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive cross-coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere such as nitrogen or argon to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.