Description

n-Demethyl Mecamylamine is a key pharmaceutical intermediate and research chemical, primarily recognized for its role in the synthesis of advanced active pharmaceutical ingredients (APIs). This compound is of significant value in medicinal chemistry for the development and study of nicotinic acetylcholine receptor (nAChR) antagonists. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of neurological and cardiovascular therapeutics, as well as for high-purity chemical synthesis.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of Mecamylamine and related nAChR antagonist APIs.
• Medicinal Chemistry Research: Used in preclinical studies and structure-activity relationship (SAR) investigations for neurological targets.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical labs.
• Biochemical Research: Employed in studies exploring the autonomic nervous system and ganglionic blocking mechanisms.
• Custom Synthesis: A starting material for the preparation of novel chemical entities and labeled compounds for research.

Basic Information

Product Name	n-Demethyl Mecamylamine
CAS No.	859995-07-6
Molecular Formula	C11H21N
Molecular Weight	167.29 g/mol
Synonyms	N-Desmethyl Mecamylamine; 2-Methyl-3-(methylamino)bornane; 3-(Methylamino)-2-methylbornane; 2-Methyl-3-(methylamino)isocamphane; Mecamylamine Impurity; Mecamylamine Related Compound A; (1R,2S,4S)-N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine
EINECS	Contact for details

Quality Control

Our n-Demethyl Mecamylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.