Description

6-Iodonordihydrocapsaicin is a halogenated analog of the natural capsaicinoid nordihydrocapsaicin, distinguished by the strategic iodine substitution on its aromatic ring. This modification is of significant interest in biochemical and pharmacological research, particularly for studying the structure-activity relationships of vanilloid receptor 1 (TRPV1) agonists and antagonists. It serves as a critical synthetic intermediate and reference standard for scientists and manufacturers in the pharmaceutical, agrochemical, and flavor/fragrance industries.

Application

• Pharmaceutical Research & Development: A key intermediate in the synthesis of novel TRPV1 channel modulators for pain management, neuropathic disorders, and inflammation.
• Biochemical Probes: Used as a labeled or tagged molecular probe to investigate capsaicinoid binding sites and receptor interaction mechanisms.
• Agrochemical Innovation: Serves as a precursor for developing new bioactive compounds with potential pesticidal or herbicidal activity.
• Flavor & Fragrance Chemistry: Employed in the synthesis of advanced capsaicin analogs to study and modify pungency profiles and thermal perception.
• Analytical Reference Standard: Essential for the quality control and quantification of capsaicinoid mixtures in food, supplements, and pharmaceutical preparations via HPLC, LC-MS, or GC-MS.
• Academic & Institutional Research: A valuable tool for universities and research institutes studying neurobiology, sensory physiology, and medicinal chemistry.

Basic Information

Product Name	6-Iodonordihydrocapsaicin
CAS No.	859171-97-4
Molecular Formula	C17H26INO3
Molecular Weight	419.30 g/mol
Synonyms	6-Iodo-Nordihydrocapsaicin; N-[(4-Hydroxy-3-iodo-5-methoxyphenyl)methyl]-8-methylnonanamide; 6-I-NDHC; 6-Iodo-Dihydrocapsaicin analog; Iodonordihydrocapsaicin; Vanillylamide of 8-methyl-6-iodononanoic acid; (E)-8-Methyl-N-vanillyl-6-iodononenamide
EINECS	Contact for details

Quality Control

Our 6-Iodonordihydrocapsaicin is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation via NMR and MS. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.