Description

4-Bromomethyl-1,1-difluoro-cyclohexane is a versatile fluorinated and brominated cyclohexane derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromomethyl and gem-difluoro functional groups on the cyclohexane ring, makes it a valuable intermediate for introducing fluorinated motifs into target molecules. This compound is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of fluorinated drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of novel fluorinated pesticides and herbicides, where the difluoro group can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in advanced electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorine and bromine functionalities into polymer backbones, altering physical properties like solubility, thermal stability, and surface energy.
• Cross-Coupling Reactions: The bromomethyl group acts as a handle for further functionalization via palladium-catalyzed cross-coupling (e.g., Suzuki, Negishi) to create complex molecular architectures.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new methodologies in organofluorine chemistry.

Basic Information

Product Name	4-Bromomethyl-1,1-Difluoro-Cyclohexane
CAS No.	858121-94-5
Molecular Formula	C7H11BrF2
Molecular Weight	213.06 g/mol
Synonyms	1,1-Difluoro-4-(bromomethyl)cyclohexane; Cyclohexane, 4-(bromomethyl)-1,1-difluoro-; 4-(Bromomethyl)-1,1-difluorocyclohexane; 1,1-Difluoro-4-bromomethylcyclohexane
EINECS	Contact for details

Quality Control

Our 4-Bromomethyl-1,1-difluoro-cyclohexane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C, ¹⁹F), GC/HPLC, and residual solvent analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We support cGMP compliance for advanced applications and can tailor purity grades to meet specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to the light-sensitive nature of the compound, containers should be amber glass or otherwise light-protected.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.