Description

n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-L-Isovaline CAS NO 857478-30-9 is a specialized Fmoc-protected amino acid derivative, a critical building block in solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the controlled, sequential assembly of complex peptides by protecting the α-amino group of L-isovaline, a non-proteinogenic amino acid with unique structural properties. This compound is essential for researchers and manufacturers in pharmaceutical R&D, biotechnology, and fine chemical synthesis who require high-purity intermediates for creating novel peptide-based therapeutics, diagnostic agents, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected intermediate for the automated or manual synthesis of custom peptides containing the L-isovaline residue.
• Pharmaceutical Research & Development: Incorporation into novel peptide drug candidates to enhance metabolic stability, alter pharmacokinetics, or introduce specific conformational constraints.
• Bioconjugation & Probe Development: Used in the synthesis of peptide-based probes, tags, and linkers for chemical biology studies and diagnostic applications.
• Fine Chemical & Custom Synthesis: Serves as a chiral building block for the preparation of more complex non-natural amino acids, peptidomimetics, and other specialized organic molecules.
• Academic Research: Fundamental studies in peptide chemistry, structure-activity relationships (SAR), and the exploration of novel bioactive sequences.

Basic Information

Product Name	n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-L-Isovaline
CAS No.	857478-30-9
Molecular Formula	C20H21NO4
Molecular Weight	339.39 g/mol
Synonyms	Fmoc-L-isovaline; Fmoc-Iva-OH; N-[(9-Fluorenylmethoxy)carbonyl]-L-isovaline; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanoic acid; N-Fmoc-L-isovaline; Fmoc-L-Iva; N-α-Fmoc-L-isovaline; L-Isovaline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-L-Isovaline is manufactured under strict quality control protocols to ensure high chemical purity and consistency, meeting the exacting standards required for peptide synthesis. Each batch is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles is provided to guarantee suitability for research and cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.