Description

n-(2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanesulfonamide is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester group. This compound is critically important as a key building block in modern medicinal chemistry, specifically for Suzuki-Miyaura cross-coupling reactions. It is primarily required by R&D and production teams in the pharmaceutical and agrochemical industries for the synthesis of novel, complex molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs) via palladium-catalyzed cross-coupling.
• Suzuki-Miyaura Coupling Reagent: Enables the formation of carbon-carbon bonds to create biaryl structures, a common motif in drug discovery.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides requiring specific fluorinated aryl structures.
• Material Science: Serves as a precursor for organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology: Employed in the synthesis of probes and ligands for target identification and validation studies.
• Custom Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule development.

Basic Information

Product Name	n-(2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanesulfonamide
CAS No.	856898-43-6
Molecular Formula	C₁₃H₁₉BFNO₄S
Molecular Weight	327.17 g/mol
Synonyms	2-Fluoro-4-(N-methanesulfonylamino)phenylboronic acid pinacol ester; 4-(N-Methanesulfonylamino)-2-fluorophenylboronic acid pinacol ester; 2-Fluoro-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide; 4-(Methanesulfonamido)-2-fluorophenylboronic acid pinacol ester; 856898-43-6; BRN 12505064
EINECS	Contact for details

Quality Control

Every batch of our n-(2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanesulfonamide is manufactured under strict quality management systems and undergoes rigorous analytical testing. We ensure compliance with ICH guidelines for impurities and provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our commitment to cGMP standards guarantees batch-to-batch consistency for critical pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area %)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.