Description

5-Hexenoic Acid, 2-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Methylamino]-, (2S)- is a specialized, chiral amino acid derivative featuring a reactive terminal alkene group and an Fmoc-protected amine. This compound matters as a high-value building block for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics, enabling the introduction of unique structural motifs. It is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and the development of novel bioactive molecules.

Application

• Peptide Synthesis Building Block: A key chiral intermediate for incorporating non-natural amino acid residues with an alkene side chain into peptide sequences via Fmoc-based SPPS (Solid-Phase Peptide Synthesis).
• Medicinal Chemistry & Drug Discovery: Used in the research and development of new therapeutic agents, particularly for creating constrained peptides or for post-synthetic modification via click chemistry (e.g., thiol-ene reactions).
• Bioconjugation & Probe Development: The alkene functionality allows for site-specific labeling or conjugation to other molecules (like fluorophores or polymers), useful for creating diagnostic probes or ADC (Antibody-Drug Conjugate) linkers.
• Chemical Biology Research: Employed in studying protein-protein interactions, enzyme mechanisms, and cellular processes by introducing specific, modifiable handles into synthetic peptides.
• Material Science & Polymer Chemistry: Serves as a monomer or cross-linking agent for synthesizing specialized polymers with peptide-like backbones or functional groups.

Basic Information

Product Name	5-Hexenoic Acid, 2-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Methylamino]-, (2S)-
CAS No.	856412-21-0
Molecular Formula	C23H25NO5
Molecular Weight	395.45 g/mol
Synonyms	(2S)-2-[(Fmoc-N-methylamino)pent-4-enoic acid; Fmoc-N-Me-δPhe-OH; Fmoc-N-methyl-4-pentenoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-allylglycine; Nα-Fmoc-Nα-methyl-L-2-amino-5-hexenoic acid; N-Fmoc-N-methyl-L-2-amino-5-hexenoic acid; L-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-5-hexenoic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. For this high-purity building block, typical QC includes HPLC purity analysis, chiral purity verification, and structural confirmation to meet the exacting requirements of pharmaceutical research and process development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥99.0% (S-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.