Description

9,9-Dimethyl-4,5-Bis(Di-T-Butylphosphino)Xanthene, Min. 97% T-Bu-Xantphos is a high-purity, sterically demanding bidentate phosphine ligand essential for advanced cross-coupling catalysis. Its value lies in enabling highly efficient and selective palladium-catalyzed reactions, particularly for challenging substrates where traditional ligands fail. This product is critically needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries for developing novel synthetic routes and scaling up production of complex molecules.

Application

• Pharmaceutical Intermediate Synthesis: A key ligand for Buchwald-Hartwig amination, Suzuki-Miyaura, and Negishi cross-couplings in API manufacturing.
• Agrochemical Production: Enables the construction of complex heterocyclic structures found in modern pesticides and herbicides.
• Fine Chemical & Specialty Material Manufacturing: Used in the synthesis of OLED materials, liquid crystals, and other performance chemicals.
• Academic & Industrial R&D: A staple ligand for methodology development and exploring new C-C and C-heteroatom bond-forming reactions.
• Catalyst Precursor Preparation: Forms active palladium complexes for homogeneous catalysis with enhanced stability and activity.
• Process Chemistry Optimization: Improves yield and selectivity in large-scale manufacturing, reducing waste and cost.

Basic Information

Product Name	9,9-Dimethyl-4,5-Bis(Di-T-Butylphosphino)Xanthene, Min. 97% T-Bu-Xantphos
CAS No.	856405-77-1
Molecular Formula	C33H52O1P2
Molecular Weight	526.71 g/mol
Synonyms	T-Bu-Xantphos; 4,5-Bis(di-tert-butylphosphino)-9,9-dimethylxanthene; 9,9-Dimethyl-4,5-bis(di-tert-butylphosphino)xanthene; Di-tert-butyl Xantphos; DTBPX; Xantphos Derivative; Bidentate Phosphine Ligand; CAS 856405-77-1
EINECS	Contact for details

Quality Control

Every batch of T-Bu-Xantphos is produced and tested under strict quality management protocols to ensure consistent high performance in catalytic applications. Our products undergo rigorous quality testing, including HPLC and NMR analysis, to verify identity, purity, and the absence of critical impurities like phosphine oxides. Certificates of Analysis (COA) with detailed chromatographic data are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation, containers should be flushed with inert gas before resealing after use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	Min. 97.0%
Melting Point	Contact for details
Loss on Drying	< 0.5%
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.