Description

3-Bromo-n-Cyclopropyl-4-Methylbenzamide is a high-purity, advanced pharmaceutical intermediate characterized by its distinct brominated aromatic and cyclopropylamide structure. This compound matters for its critical role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular scaffolds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders or possessing kinase inhibitory activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its versatile bromine handle for further functionalization.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides or fungicides, where the cyclopropyl group can impart specific biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis or metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function or protein-protein interactions.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.

Basic Information

Product Name	3-Bromo-n-Cyclopropyl-4-Methylbenzamide
CAS No.	856252-70-5
Molecular Formula	C11H12BrNO
Molecular Weight	254.13 g/mol
Synonyms	3-Bromo-N-cyclopropyl-4-methylbenzamide; 4-Methyl-3-bromo-N-cyclopropylbenzamide; Benzamide, 3-bromo-N-cyclopropyl-4-methyl-; 3-Bromo-4-methyl-N-cyclopropylbenzamide; N-Cyclopropyl-3-bromo-4-methylbenzamide; 856252-70-5; AI3-52362
EINECS	Contact for details

Quality Control

Our 3-Bromo-n-Cyclopropyl-4-Methylbenzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.