Description

Fmoc-D-2,6-Dimethyltyrosine is a protected, non-natural amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for introducing the unique steric and electronic properties of the D-2,6-dimethyltyrosine side chain into peptide sequences, enabling the development of novel bioactive molecules with enhanced stability and receptor selectivity. It is an essential building block for pharmaceutical researchers and peptide chemists working in drug discovery, proteomics, and the development of peptide-based therapeutics and diagnostics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides, particularly those requiring the incorporation of D-configured, sterically hindered tyrosine analogs.
• Pharmaceutical Research & Drug Discovery: Used to create peptide libraries and novel lead compounds with improved metabolic stability, bioavailability, and target specificity for therapeutic applications.
• Peptidomimetic Development: Essential for designing and synthesizing peptidomimetics where the dimethylated aromatic ring system modulates peptide conformation and interaction with biological targets.
• Bioconjugation & Probe Synthesis: Serves as a precursor for creating labeled peptides or peptide-based probes for biochemical assays, imaging, and diagnostic tools.
• Academic & Industrial R&D: A fundamental reagent in laboratories focused on organic synthesis, medicinal chemistry, and the study of structure-activity relationships (SAR) in peptides.

Basic Information

Product Name	Fmoc-D-2,6-Dimethyltyrosine
CAS No.	854300-32-6
Molecular Formula	C26H25NO5
Molecular Weight	431.48 g/mol
Synonyms	Fmoc-D-2,6-dimethyl-Tyr-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2,6-dimethyl-4-hydroxyphenyl)-D-alanine; Fmoc-D-(2,6-Me2)Tyr-OH; D-2,6-Dimethyltyrosine, N-Fmoc derivative; N-α-Fmoc-D-2,6-dimethyltyrosine; Fmoc-D-2,6-DMT; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-hydroxy-2,6-dimethylphenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-D-2,6-Dimethyltyrosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for advanced peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee consistent quality, lot-to-lot reproducibility, and traceability for your research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under anhydrous conditions, preferably with desiccant, to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.