Description

D-Erythro-2-n-[6'-(1"-Pyridinium)-Hexanoyl]-Sphingosine Bromide is a high-purity, synthetic sphingolipid derivative, specifically a cationic ceramide analog, that serves as a critical biochemical tool and a key intermediate in advanced research. Its primary value lies in its role as a cell-permeable modulator of sphingolipid metabolism and signaling pathways, enabling the study of apoptosis, cell differentiation, and membrane biology. This compound is essential for researchers and developers in the pharmaceutical, biotechnology, and life science sectors, particularly for investigating novel therapeutic targets related to cancer, neurodegenerative diseases, and metabolic disorders.

Application

• Biochemical Research: A fundamental tool for studying the role of ceramides and sphingolipid signaling in cellular processes such as apoptosis, autophagy, and stress responses.
• Pharmaceutical Development: Used as a reference standard, a key intermediate, or a bioactive compound in the discovery and development of novel therapeutics targeting cancer and inflammatory diseases.
• Cell Biology Studies: Employed to modulate intracellular ceramide levels and investigate its effects on cell cycle regulation, differentiation, and senescence in various cell lines.
• Lipidomics & Analytical Standards: Serves as a high-purity standard for mass spectrometry (MS), high-performance liquid chromatography (HPLC), and other analytical techniques in lipid profiling and quantification.
• Signal Transduction Research: Critical for elucidating the downstream effects of ceramide-mediated pathways on protein kinases, phosphatases, and other signaling molecules.
• Drug Delivery & Formulation Studies: Investigated for its potential in designing lipid-based nanoparticle carriers due to its cationic pyridinium head group and amphiphilic structure.

Basic Information

Product Name	D-Erythro-2-n-[6'-(1"-Pyridinium)-Hexanoyl]-Sphingosine Bromide
CAS No.	853992-70-8
Molecular Formula	C29H51BrN2O3
Molecular Weight	555.64 g/mol
Synonyms	C6-Pyridinium Ceramide Bromide; C6-Py-Cer; N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-6-(1-pyridinio)hexanamide Bromide; LCL 30; D-erythro-C6-Pyridinium-Ceramide Bromide; (2S,3R,4E)-2-Amino-3-hydroxy-4-octadecene-1,3-diol 6-(1-Pyridinium)hexanoate Bromide; Ceramide C6 Pyridinium Salt
EINECS	Contact for details

Quality Control

Our D-Erythro-2-n-[6'-(1"-Pyridinium)-Hexanoyl]-Sphingosine Bromide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. All products undergo rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.