Description

(3-Amino-2-Hydroxy-Propyl)-Carbamic Acid tert-Butyl Ester CAS NO 853944-08-8 is a key Boc-protected amino alcohol building block used in advanced organic synthesis. This compound is critical for researchers and manufacturers requiring high-purity intermediates for constructing complex molecules with precise stereochemistry. It is primarily utilized in the pharmaceutical industry for the development of active pharmaceutical ingredients (APIs) and in peptide synthesis.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in oncology and neurology research.
• Peptide Synthesis: Used to introduce the 3-amino-2-hydroxypropyl moiety into peptide chains, modifying their biological activity and stability.
• Chiral Auxiliary & Ligand Synthesis: Serves as a precursor for creating chiral ligands used in asymmetric catalysis.
• Bioconjugation Chemistry: Employed in the modification of biomolecules for drug delivery systems and diagnostic applications.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) group provides orthogonal protection for amines in multi-step synthetic sequences.
• Academic & R&D: A valuable reagent for medicinal chemistry and chemical biology research in academic and industrial laboratories.

Basic Information

Product Name	(3-Amino-2-Hydroxy-Propyl)-Carbamic Acid tert-Butyl Ester
CAS No.	853944-08-8
Molecular Formula	C8H18N2O3
Molecular Weight	190.24 g/mol
Synonyms	tert-Butyl N-(3-amino-2-hydroxypropyl)carbamate; 1-Amino-3-[(tert-butoxycarbonyl)amino]-2-propanol; 3-[(tert-Butoxycarbonyl)amino]-2-hydroxypropylamine; Boc-1,3-diamino-2-propanol; N-Boc-1,3-diamino-2-propanol; N-(tert-Butoxycarbonyl)-1,3-diamino-2-propanol; 2-Hydroxy-1,3-propanediamine, N1-Boc derivative
EINECS	Contact for details

Quality Control

Our (3-Amino-2-Hydroxy-Propyl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.