Description

4-Bromo-2-(trifluoromethoxy)anisole is a high-purity, multi-functional aromatic building block featuring bromine and trifluoromethoxy substituents, which are critical for modulating the electronic and steric properties of target molecules. This compound is essential for advanced organic synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Active Ingredient Development: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances bioavailability and metabolic stability.
• Liquid Crystal & OLED Material Synthesis: Serves as a precursor for creating specialized aromatic cores in electronic display and lighting materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to form new carbon-carbon and carbon-heteroatom bonds.
• Functional Polymer Monomer: Incorporated into polymer backbones to impart specific properties like chemical resistance or altered refractive index.
• Chemical Research & Development: A versatile reagent in academic and industrial labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	4-Bromo-2-(trifluoromethoxy)anisole
CAS No.	853771-88-7
Molecular Formula	C8H6BrF3O2
Molecular Weight	271.04 g/mol
Synonyms	1-Bromo-4-methoxy-3-(trifluoromethoxy)benzene; 4-Bromo-2-(trifluoromethoxy)-1-methoxybenzene; 3-(Trifluoromethoxy)-4-bromoanisole; 4-Bromo-3-(trifluoromethoxy)anisole; Anisole, 4-bromo-2-(trifluoromethoxy)-; Benzene, 1-bromo-4-methoxy-3-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(trifluoromethoxy)anisole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.