Description

3-(4-Fluoro-Phenylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a fluorinated aniline and a protected pyrrolidine carboxylic acid. This compound is a critical building block for medicinal chemists, enabling the synthesis of novel drug candidates with enhanced metabolic stability and target affinity. It is primarily utilized in the research and development of new therapeutic agents within the pharmaceutical and biotechnology sectors.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of potential drug molecules, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop compounds with improved pharmacokinetic properties.
• Protease Inhibitor Development: Serves as a core scaffold or precursor for inhibitors targeting various protease enzymes.
• Chemical Biology Probes: Employed in the creation of tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for custom synthesis projects and scale-up activities.

Basic Information

Product Name	3-(4-Fluoro-Phenylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	853577-87-4
Molecular Formula	C15H21FN2O2
Molecular Weight	280.34 g/mol
Synonyms	tert-Butyl 3-[(4-fluorophenyl)amino]pyrrolidine-1-carboxylate; 1-Boc-3-(4-fluoroanilino)pyrrolidine; 3-(4-Fluoroanilino)-1-(tert-butoxycarbonyl)pyrrolidine; 1-(tert-Butoxycarbonyl)-3-(4-fluoroanilino)pyrrolidine; 853577-87-4; Pyrrolidine-1-carboxylic acid, 3-[(4-fluorophenyl)amino]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 3-(4-Fluoro-Phenylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all specifications and test results. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.