Description

(5-Bromo-2-Fluorophenyl)(Piperidin-1-Yl)Methanone is a high-purity, advanced pharmaceutical intermediate characterized by its bromo-fluorophenyl and piperidine carbonyl structure. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated aromatic and amide functionalities into target molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its halogen and amide motifs.
• Agrochemical Synthesis: Serves as a building block for developing new pesticides and herbicides, where the bromo-fluorophenyl group can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for catalysis or as a core structure in functional materials research.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scaled-up production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	(5-Bromo-2-Fluorophenyl)(Piperidin-1-Yl)Methanone
CAS No.	853313-13-0
Molecular Formula	C12H13BrFNO
Molecular Weight	286.14 g/mol
Synonyms	1-(5-Bromo-2-fluorobenzoyl)piperidine; (5-Bromo-2-fluorophenyl)(piperidin-1-yl)methanone; 5-Bromo-2-fluoro-N-piperidin-1-ylbenzamide; 853313-13-0; Methanone, (5-bromo-2-fluorophenyl)-1-piperidinyl-; 5-Bromo-2-fluorobenzoic acid piperidide; Piperidine, 1-(5-bromo-2-fluorobenzoyl)-
EINECS	Contact for details

Quality Control

Our (5-Bromo-2-Fluorophenyl)(Piperidin-1-Yl)Methanone is manufactured under strict quality management systems. Every batch is subjected to rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to ISO 9001 standards, and we support development under ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.