Description

2-Chloro-4-Fluorophenylacetic Acid Ethyl Ester is a high-purity fluorinated aromatic ester building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Serves as a crucial precursor in the development of next-generation herbicides and fungicides, where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Research: Used in the synthesis of fluorinated aromatic cores for advanced electronic materials, contributing to improved performance in display and lighting technologies.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Heck) and ester hydrolysis/transformation reactions to introduce the 2-chloro-4-fluorophenyl moiety into more complex structures.
• Chemical Research & Development: Essential for medicinal chemistry programs and process chemistry optimization in both academic and industrial R&D laboratories.

Basic Information

Product Name	2-Chloro-4-Fluorophenylacetic Acid Ethyl Ester
CAS No.	853301-97-0
Molecular Formula	C10H10ClFO2
Molecular Weight	216.64 g/mol
Synonyms	Ethyl (2-chloro-4-fluorophenyl)acetate; 2-Chloro-4-fluorobenzeneacetic acid ethyl ester; (2-Chloro-4-fluorophenyl)acetic acid ethyl ester; Ethyl 2-(2-chloro-4-fluorophenyl)acetate; NSC 405124; 853301-97-0; 2-Chloro-4-fluoro-α-toluic acid ethyl ester
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-Fluorophenylacetic Acid Ethyl Ester is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and consistency for your critical R&D and production processes. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles via HPLC, GC, and NMR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.