Description

1-Methoxy-4-(Pentafluorosulfanyl)Benzene is a high-value fluorinated aromatic building block characterized by the unique and highly electronegative pentafluorosulfanyl (SF5) group. This compound matters for its ability to dramatically alter the physicochemical properties of target molecules, enhancing metabolic stability, lipophilicity, and overall bioactivity. It is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, as well as by material scientists exploring advanced polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon for introducing the SF5 pharmacophore into drug candidates to improve potency and ADMET properties.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Advanced Material Research: Serves as a monomer or precursor for specialty polymers, liquid crystals, and electronic materials requiring high thermal and chemical stability.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex, fluorinated aromatic systems for various R&D applications.
• Ligand and Catalyst Development: Utilized to synthesize novel ligands for catalysis, where the SF5 group can significantly influence electronic properties and steric bulk.

Basic Information

Product Name	1-Methoxy-4-(Pentafluorosulfanyl)Benzene
CAS No.	852469-75-1
Molecular Formula	C7H5F5OS
Molecular Weight	232.17 g/mol
Synonyms	4-Methoxyphenylsulfur pentafluoride; p-Methoxyphenylsulfur pentafluoride; 4-(Pentafluorosulfanyl)anisole; 1-Methoxy-4-(SF5)benzene; Anisole, 4-(pentafluorosulfanyl)-; SF5-Anisole; 4-SF5-Anisole; 4-Methoxybenzenesulfonyl pentafluoride (common misnomer)
EINECS	Contact for details

Quality Control

Our 1-Methoxy-4-(Pentafluorosulfanyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development and cGMP manufacturing needs with appropriate documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.