Description

5-Nitro-2-[(Tetrahydro-Furan-2-Ylmethyl)-Amino]-Benzonitrile is a specialized aromatic nitrile derivative that serves as a high-value synthetic intermediate in advanced organic synthesis. Its molecular structure, featuring both nitro and nitrile functional groups on an aniline core, makes it a versatile building block for constructing complex heterocyclic systems and pharmacologically active molecules. This compound is primarily sought after by research institutions and pharmaceutical development companies engaged in the discovery of new active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Research: Used as a building block for developing new herbicides, fungicides, and plant growth regulators with specific mode-of-action profiles.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic electronic materials.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, activity-based probes (ABPs), and photoaffinity labels for studying enzyme function.
• Dye & Pigment Synthesis: Intermediate for producing specialized azo dyes and pigments with unique colorfastness and spectral properties.
• Academic & Contract Research: Essential reagent for methodological development in organic chemistry and for exploring new catalytic reactions and bond-forming transformations.

Basic Information

Product Name	5-Nitro-2-[(Tetrahydro-Furan-2-Ylmethyl)-Amino]-Benzonitrile
CAS No.	852216-14-9
Molecular Formula	C₁₃H₁₅N₃O₃
Molecular Weight	261.28 g/mol
Synonyms	2-[(Tetrahydrofuran-2-ylmethyl)amino]-5-nitrobenzonitrile; 5-Nitro-2-[(tetrahydro-2-furanylmethyl)amino]benzonitrile; N-(Tetrahydrofurfuryl)-2-cyano-4-nitroaniline; 2-Amino-5-nitrobenzonitrile, N-(tetrahydro-2-furanylmethyl)-; Benzonitrile, 5-nitro-2-[(tetrahydro-2-furanylmethyl)amino]-; 852216-14-9; N-(Tetrahydro-2-furylmethyl)-2-cyano-4-nitroaniline
EINECS	Contact for details

Quality Control

Our 5-Nitro-2-[(Tetrahydro-Furan-2-Ylmethyl)-Amino]-Benzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the stringent requirements for research and development applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results. We support cGMP-compliant production for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature, the container should be amber-colored or stored in a light-proof secondary packaging. For long-term storage, consider maintaining the material under an inert atmosphere (e.g., nitrogen or argon) to minimize potential oxidation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.