Description

1,2-Dioctanoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3',4',5'-Trisphosphate) (Ammonium Salt) is a synthetic, water-soluble phosphoinositide analog, specifically a diC8-PI(3,4,5)P3, that serves as a critical tool compound for studying intracellular signaling pathways. This high-purity lipid is essential for researchers investigating the role of phosphatidylinositol (3,4,5)-trisphosphate in cellular processes such as cell growth, proliferation, and survival. It is primarily utilized by pharmaceutical R&D teams, academic biochemistry laboratories, and biotechnology companies focused on signal transduction, drug discovery for oncology, and metabolic disease research.

Application

• Biochemical Research: As a key agonist/activator for studying PI3K/Akt/mTOR signaling pathways in vitro.
• Drug Discovery Screening: Used in high-throughput assays to identify and characterize inhibitors of phosphoinositide-binding domains (e.g., PH domains).
• Cell Biology Studies: Investigation of membrane recruitment, protein-lipid interactions, and second messenger functions in cell models.
• Enzyme Kinetics: Substrate for phosphatases (e.g., PTEN, SHIP) and kinases to study enzymatic activity and regulation.
• Liposome & Membrane Biophysics: Component for constructing defined lipid bilayers to model cellular membranes and study lipid-protein interactions.
• Diagnostic Development: Potential use in developing assays for detecting abnormalities in phosphoinositide metabolism.

Basic Information

Product Name	1,2-Dioctanoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3',4',5'-Trisphosphate) (Ammonium Salt)
CAS No.	852043-38-0
Molecular Formula	C29H61N3O22P4
Molecular Weight	915.73 g/mol
Synonyms	PI(3,4,5)P3 (diC8); L-α-Phosphatidylinositol-3,4,5-trisphosphate (C8); diC8-PI(3,4,5)P3; 1,2-Di-O-octanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) ammonium salt; Phosphatidylinositol (3,4,5)-trisphosphate diC8; PtdIns(3,4,5)P3 (C8); PIP3 (diC8); Ammonium 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-trisphosphate)
EINECS	Contact for details

Quality Control

This high-value biochemical is manufactured under strict quality control protocols to ensure batch-to-batch consistency and structural integrity. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity, purity, and the absence of critical impurities like lysophospholipids. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and solvent content is provided with every shipment to support your research and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to prevent oxidation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (P Content)	≥ 98%
Solvent Content (Residual)	< 2%
Water Content (KF)	< 1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.