Description

Benzoic Acid, 2-[[3,5-Dichloro-4-[[17-(2-Pyridinyldithio)-3,6,9,12,15-Pentaoxaheptadec-1-Yl]Oxy]Phenyl]Amino]- is a sophisticated bifunctional chemical building block that integrates a benzoic acid core with a hydrophilic polyethylene glycol (PEG) linker and a reactive pyridinyldithio group. This compound matters for its unique ability to serve as a versatile linker in bioconjugation and targeted drug delivery systems, enabling the stable attachment of therapeutic payloads to targeting molecules like antibodies. It is primarily needed by research scientists and process developers in the pharmaceutical, biotechnology, and diagnostic reagent industries who are developing next-generation ADC (Antibody-Drug Conjugate) therapies and advanced bioconjugates.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key intermediate for constructing cleavable linkers that connect cytotoxic drugs to monoclonal antibodies via a disulfide bridge.
• Protein and Peptide Modification: Used for site-specific conjugation of drugs, dyes, or other functional molecules to proteins, leveraging the reactive pyridyldithiol group for thiol coupling.
• Nanoparticle Functionalization: Imparts surface functionality to liposomes, polymeric nanoparticles, or quantum dots for targeted delivery and enhanced biocompatibility.
• Prodrug Synthesis: Employed in the design of stimuli-responsive prodrugs where the linker is cleaved in specific physiological environments (e.g., reductive tumor microenvironments).
• Diagnostic Reagent Development: Serves as a linker for attaching signal molecules (e.g., fluorophores, chelators) to antibodies or other targeting agents for in vitro diagnostics (IVD) and imaging.
• Biomaterial Surface Engineering: Used to create functionalized surfaces on medical devices or scaffolds for controlled biomolecule immobilization.

Basic Information

Product Name	Benzoic Acid, 2-[[3,5-Dichloro-4-[[17-(2-Pyridinyldithio)-3,6,9,12,15-Pentaoxaheptadec-1-Yl]Oxy]Phenyl]Amino]-
CAS No.	851962-15-7
Molecular Formula	C31H37Cl2N3O8S2
Molecular Weight	722.67 g/mol
Synonyms	2-((3,5-Dichloro-4-((17-(2-pyridinyldithio)-3,6,9,12,15-pentaoxaheptadec-1-yl)oxy)phenyl)amino)benzoic acid; PEG5-SPDP Benzoic Acid Derivative; SPDP-PEG5-Benzoic Acid; Heterobifunctional PEG Linker, Pyridyldithiol-PEG5-Benzoic Acid; ADC Linker Intermediate; SS-PEG5-BA; N-Succinimidyl 3-(2-pyridyldithio)propionate-PEG5 Benzoate Analog; Cleavable Disulfide Linker Reagent
EINECS	Contact for details

Quality Control

Every batch of this high-value linker is produced and analyzed under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity meet the exacting standards required for bioconjugation research and cGMP manufacturing support. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and functional performance data is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Functional Activity	≥ 90% (by thiol-disulfide exchange assay)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.