Description

Benzoic Acid, 2-[[3,5-Dichloro-4-[2-[2-[2-(2-Pyridinyldithio)Ethoxy]Ethoxy]Ethoxy]Phenyl]Amino]- (CAS 851962-12-4) is a sophisticated bifunctional chemical compound designed for advanced bioconjugation and cross-linking applications. This molecule integrates a reactive benzoic acid derivative with a cleavable disulfide linker, enabling precise and reversible attachment to target molecules. It is a critical reagent for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require controlled and reversible protein modification, drug delivery system development, and advanced material science.

Application

• Bioconjugation Reagent: For the site-specific and reversible conjugation of peptides, proteins, and antibodies, facilitating targeted drug delivery and diagnostic probe development.
• Cross-linking Agent: Used in the synthesis of cleavable cross-linked polymers, hydrogels, and biomaterials where controlled release or degradation is required.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly those utilizing antibody-drug conjugates (ADCs) or prodrug strategies.
• Surface Functionalization: Enables the modification of nanoparticles, biosensors, and chromatography media with reversible binding properties.
• Chemical Biology Research: A vital tool for studying protein-protein interactions, cellular uptake mechanisms, and intracellular trafficking via disulfide bond reduction.
• Linker for Solid-Phase Synthesis: Employed in peptide and oligonucleotide synthesis as a cleavable linker for the controlled release of synthesized products.

Basic Information

Product Name	Benzoic Acid, 2-[[3,5-Dichloro-4-[2-[2-[2-(2-Pyridinyldithio)Ethoxy]Ethoxy]Ethoxy]Phenyl]Amino]-
CAS No.	851962-12-4
Molecular Formula	C25H26Cl2N2O5S2
Molecular Weight	577.52 g/mol
Synonyms	2-[[3,5-Dichloro-4-[2-[2-[2-(2-Pyridinyldithio)ethoxy]ethoxy]ethoxy]phenyl]amino]benzoic acid; 2-((4-((2-(2-(2-(Pyridin-2-yldisulfanyl)ethoxy)ethoxy)ethoxy)-3,5-dichlorophenyl)amino)benzoic acid; SPDP-PEG3-Benzoic Acid derivative; Cleavable PEGylated benzoic acid crosslinker; Heterobifunctional disulfide linker; N-(4-(2-(2-(2-(Pyridin-2-yldisulfanyl)ethoxy)ethoxy)ethoxy)-3,5-dichlorophenyl)anthranilic acid
EINECS	Contact for details

Quality Control

Our production of this high-purity biochemical reagent adheres to stringent quality management protocols. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your research and development documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled temperature between -20°C to -10°C for long-term stability. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere or with desiccant to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Single Impurity (HPLC)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.