Description

3H-Diazirine-3-Propanoic Acid, α-(Acetylamino)-3-Methyl- is a specialized, high-purity chemical building block designed for advanced research and synthesis. This compound is valued for its unique diazirine functional group, which enables precise photoaffinity labeling and cross-linking studies in chemical biology and proteomics. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies developing next-generation therapeutics and diagnostic tools. Our supply ensures consistent quality and reliable availability for critical development workflows.

Application

• Photoaffinity Labeling Probes: Acts as a key precursor for synthesizing photoactivatable cross-linkers to study protein-ligand interactions and molecular binding sites.
• Chemical Biology Research: Used in the development of activity-based protein profiling (ABPP) reagents to identify enzyme function and activity in complex biological systems.
• Proteomics & Bioconjugation: Enables the creation of covalent probes for mapping protein structures, networks, and post-translational modifications.
• Pharmaceutical R&D: Serves as a critical intermediate in the discovery and development of targeted therapies and diagnostic agents.
• Material Science: Potential use in the synthesis of novel polymers and surfaces with photo-responsive properties.

Basic Information

Product Name	3H-Diazirine-3-Propanoic Acid, α-(Acetylamino)-3-Methyl-
CAS No.	851960-88-8
Molecular Formula	C9H13N3O3
Molecular Weight	211.22 g/mol
Synonyms	3-Methyl-3H-diazirine-3-propanoic acid, α-(acetylamino)-; α-(Acetylamino)-3-methyl-3H-diazirine-3-propanoic acid; 3-(3-Methyl-3H-diazirin-3-yl)-2-acetamidopropanoic acid; Diazirine-AA; Photo-leucine analog precursor; Ac-L-Photo-Leucine precursor; (2-Acetamido-3-(3-methyl-3H-diazirin-3-yl)propanoic acid); 851960-88-8
EINECS	Contact for details

Quality Control

Every batch of 3H-Diazirine-3-Propanoic Acid, α-(Acetylamino)-3-Methyl- is manufactured and tested under strict quality management systems. We guarantee high purity and lot-to-lot consistency suitable for sensitive research applications. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to verify identity, purity, and stability. A Certificate of Analysis (COA) documenting all specifications is provided with each shipment to ensure full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is strictly light-sensitive and must be protected from all light exposure during storage and handling to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.