Description

(S)-n-Fmoc-2-(3'-Butenyl)Glycine is a non-proteinogenic, Fmoc-protected amino acid derivative featuring a reactive butenyl side chain. This compound is a crucial chiral building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of unique structural elements into peptide sequences. It is primarily utilized by research scientists and process chemists in pharmaceutical R&D and biotechnology for developing novel therapeutic peptides, peptidomimetics, and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides, especially those requiring side-chain functionalization.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based drugs, including antimicrobial peptides, hormone analogs, and targeted therapeutics.
• Peptidomimetic Design: Serves as a precursor for creating peptidomimetics, where the butenyl side chain can be further modified via click chemistry or other cross-coupling reactions.
• Bioconjugation and Labeling: The alkene functionality allows for site-specific conjugation with thiols or other reagents via thiol-ene or other coupling chemistries for creating labeled peptides.
• Chemical Biology Probes: Enables the synthesis of activity-based probes or affinity tags to study protein-protein interactions and enzyme function.
• Academic Research: Employed in university and institutional labs for fundamental studies in organic chemistry, peptide science, and medicinal chemistry.

Basic Information

Product Name	(S)-n-Fmoc-2-(3'-Butenyl)Glycine
CAS No.	851909-08-5
Molecular Formula	C22H23NO4
Molecular Weight	365.42 g/mol
Synonyms	Fmoc-(S)-2-(3-Butenyl)glycine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pent-4-enoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-butenyl-L-glycine; Fmoc-L-2-(3-Butenyl)glycine; (S)-N-Fmoc-2-(3-Buten-1-yl)glycine; N-α-Fmoc-L-2-(3-Butenyl)glycine; Fmoc-Butenylgly-OH; L-Fmoc-2-(3-Butenyl)glycine
EINECS	Contact for details

Quality Control

Our (S)-n-Fmoc-2-(3'-Butenyl)Glycine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) detailing identity, purity (typically ≥98%), and specific impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.