Description

Dl-Threo-Ritalinic Acid Hydrochloride is a key intermediate in the synthesis of pharmaceutical compounds. This compound is of significant commercial interest for its role in the production of active pharmaceutical ingredients (APIs) and for research into central nervous system (CNS) agents. It is primarily required by pharmaceutical manufacturers, research institutions, and fine chemical suppliers engaged in the development and production of specialized therapeutics.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of methylphenidate hydrochloride and related CNS-active compounds.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the research and manufacturing of APIs targeting neurological conditions.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development, validation, and quality control testing.
• Pharmacological Research: Employed in academic and industrial R&D for studying drug metabolism, pharmacokinetics, and structure-activity relationships (SAR).
• Fine Chemical Synthesis: Utilized in multi-step organic synthesis to create novel chemical entities for screening and development.
• Impurity Standard: Acts as a known impurity standard for the analysis and control of related pharmaceutical products.

Basic Information

Item	Details
Product Name	Dl-Threo-Ritalinic Acid Hydrochloride
CAS No.	851895-37-9
Molecular Formula	C14H19NO2·HCl
Molecular Weight	269.77 g/mol
Synonyms	DL-threo-Ritalinic acid hydrochloride; (±)-threo-Methyl 2-phenyl-2-(piperidin-2-yl)acetate hydrochloride; Methylphenidate acid hydrochloride; DL-threo-Methylphenidate acid HCl; Ritalinic acid, DL-threo-, hydrochloride; 2-Phenyl-2-(2-piperidyl)acetic acid methyl ester hydrochloride; Methyl α-phenyl-α-(2-piperidyl)acetate hydrochloride
EINECS	Contact for details

Quality Control

Our Dl-Threo-Ritalinic Acid Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediates and research chemicals. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.