Description

1-(2,3-Difluorophenyl)-2-Methylpropan-1-One is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its difluorophenyl moiety can impart desirable metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of fluorinated organic compounds for advanced materials, such as liquid crystals, polymers, and electronic chemicals.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic and Industrial R&D: Utilized in research laboratories for methodological studies in fluorination chemistry and the exploration of new synthetic pathways.

Basic Information

Product Name	1-(2,3-Difluorophenyl)-2-Methylpropan-1-One
CAS No.	851753-90-7
Molecular Formula	C10H10F2O
Molecular Weight	184.18 g/mol
Synonyms	2,3-Difluorophenyl isobutyl ketone; 2-Methyl-1-(2,3-difluorophenyl)propan-1-one; Isobutyl 2,3-difluorophenyl ketone; 1-(2,3-Difluorophenyl)-2-methyl-1-propanone; α,α-Dimethyl-2,3-difluoroacetophenone; 2,3-Difluoro-α,α-dimethylacetophenone; 851753-90-7
EINECS	Contact for details

Quality Control

Our 1-(2,3-Difluorophenyl)-2-Methylpropan-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.