Description

Lidocaine-D10 n-Oxide is a deuterium-labeled analog of the metabolite lidocaine N-oxide, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity, isotopically enriched compound is critical for ensuring accuracy and reliability in mass spectrometry-based analyses by correcting for variations in sample preparation and instrument response. It is an essential tool for researchers and quality control laboratories in the pharmaceutical and forensic toxicology sectors, where precise measurement of lidocaine and its metabolites is required for drug development, pharmacokinetic studies, and compliance testing.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard for the accurate bioanalysis of lidocaine and its N-oxide metabolite in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to investigate the metabolic pathways and clearance rates of lidocaine.
• Forensic Toxicology: Enables precise quantification in post-mortem and clinical toxicology reports for cases involving lidocaine exposure or toxicity.
• Clinical Research: Supports studies monitoring lidocaine levels during therapeutic use, such as in antiarrhythmic therapy or local anesthesia.
• Method Development & Validation: Serves as a critical reference material for developing, optimizing, and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Quality Control in Manufacturing: Potential use in impurity profiling and stability testing of lidocaine-based pharmaceutical products.

Basic Information

Item	Detail
Product Name	Lidocaine-D10 n-Oxide
CAS No.	851528-10-4
Molecular Formula	C14H12D10N2O2
Molecular Weight	~254.36 g/mol
Synonyms	Lidocaine N-Oxide-d10; 2-(Diethylamino-d10)-N-(2,6-dimethylphenyl)acetamide 1-Oxide; Diethylamino-d10-2,6-xylidide N-Oxide; Lignocaine-d10 N-Oxide; Xylocaine-d10 N-Oxide; Deuterated Lidocaine N-Oxide; Lidocaine D10 N-Oxide; [2H10]-Lidocaine N-Oxide
EINECS	Contact for details

Quality Control

Every batch of Lidocaine-D10 n-Oxide is manufactured and analyzed under strict quality management systems to ensure the highest standards of isotopic purity and chemical identity. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic techniques, to ensure compliance with research and analytical standards. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing parameters such as isotopic purity, chemical purity, and confirmation of structure.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.