Description

(S)-(-)-[(S)-2-Di(3,5-Xylyl)Phosphinoferrocenyl][2-Di(4-Trifluoromethylphenyl)Phosphinophenyl]Methanol is a sophisticated, chiral ferrocenyl phosphine ligand, a critical component in advanced asymmetric catalysis. Its unique three-dimensional structure and electron-rich phosphine donors make it exceptionally effective for inducing high enantioselectivity in transition metal-catalyzed reactions. This ligand is indispensable for R&D chemists and process engineers in the pharmaceutical and fine chemical industries seeking to develop efficient, stereoselective synthetic routes for active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• As a chiral ligand for asymmetric hydrogenation of prochiral olefins, ketones, and imines.
• Key component in rhodium- and ruthenium-catalyzed reactions for the production of enantiomerically pure pharmaceutical intermediates.
• Catalyst for asymmetric C-C bond-forming reactions, including cross-coupling and allylic substitution.
• Enabling technology in the synthesis of chiral agrochemicals and specialty chemicals.
• Use in academic and industrial research to explore new catalytic methodologies.
• Critical for process development and scale-up of chiral drug candidates under GMP-like conditions.

Basic Information

Product Name	(S)-(-)-[(S)-2-Di(3,5-Xylyl)Phosphinoferrocenyl][2-Di(4-Trifluoromethylphenyl)Phosphinophenyl]Methanol
CAS No.	851308-48-0
Molecular Formula	C51H41F6FeOP2
Molecular Weight	886.66 g/mol
Synonyms	(S,S)-Walphos CF3; (S)-(-)-[2-Di(3,5-xylyl)phosphinoferrocenyl][2-di(4-trifluoromethylphenyl)phosphinophenyl]methanol; Walphos ligand CF3; (S)-Walphos(3,5-Xyl)(4-CF3-Ph); (S,S)-Fc-phosphine ligand; Chiral ferrocenyl diphosphine; Josiphos-type ligand derivative; Asymmetric hydrogenation ligand 851308-48-0
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested to ensure high chemical purity and chiral integrity, which are paramount for catalytic performance. Our quality assurance includes rigorous analysis by HPLC, NMR, and chiral HPLC to confirm identity, assay, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We adhere to strict internal standards to guarantee batch-to-batch consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This compound is light-sensitive and should be handled under an inert atmosphere to prevent decomposition.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.