Description

(S)-(-)-[(S)-2-Diphenylphosphinoferrocenyl][2-Bis(3,5-Dimethyl-4-Methoxyphenyl)Phosphinophenyl]Methanol is a highly sophisticated, chiral ferrocenyl phosphine ligand, prized for its ability to induce exceptional enantioselectivity in catalytic transformations. Its value lies in enabling the production of single-enantiomer intermediates critical for pharmaceuticals and advanced materials with high purity and yield. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-performance ligands for asymmetric hydrogenation, cross-coupling, and other transition metal-catalyzed reactions.

Application

• Asymmetric Hydrogenation Catalysis: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Critical for constructing stereogenic centers in active pharmaceutical ingredients (APIs), especially for cardiovascular, CNS, and oncological drugs.
• Agrochemical Active Ingredient Production: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Cross-Coupling Reactions: Facilitates asymmetric Suzuki-Miyaura, Heck, and other C-C bond-forming reactions to create complex chiral architectures.
• Fine Chemical and Fragrance Manufacturing: Enables the production of high-value chiral flavors, fragrances, and specialty chemicals.
• Academic and Industrial R&D: A valuable tool for developing new catalytic methodologies and exploring novel synthetic routes in process chemistry.

Basic Information

Product Name	(S)-(-)-[(S)-2-Diphenylphosphinoferrocenyl][2-Bis(3,5-Dimethyl-4-Methoxyphenyl)Phosphinophenyl]Methanol
CAS No.	851308-47-9
Molecular Formula	C51H48FeO3P2
Molecular Weight	802.70 g/mol
Synonyms	(S)-(-)-[2-Bis(3,5-dimethyl-4-methoxyphenyl)phosphinophenyl][(S)-2-diphenylphosphinoferrocenyl]methanol; (S,S)-Walphos; Walphos SL-W008-1; Josiphos-type ligand; Chiral ferrocenyl diphosphine ligand; (S)-[2-[Bis(3,5-dimethyl-4-methoxyphenyl)phosphino]phenyl][(S)-2-(diphenylphosphino)ferrocenyl]methanol
EINECS	Contact for details

Quality Control

Every batch of our chiral ligand is produced and analyzed under strict quality management to ensure consistency and performance. Standard quality control includes HPLC for chiral purity and assay, NMR for structural confirmation, and specific rotation measurement. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The product is light-sensitive and easily oxidized; prolonged exposure to air, light, or ambient temperature should be avoided to maintain optimal catalytic activity and purity.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation [α]	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.