Description

(S)-(-)-[(S)-2-Di(3,5-Xylyl)Phosphinoferrocenyl][2-Di(3,5-Xylyl)Phosphinophenyl]Methanol is a highly specialized, chiral ferrocenyl phosphine ligand, a critical component in asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, which are essential for the efficient and sustainable synthesis of single-enantiomer pharmaceutical intermediates and fine chemicals. This product is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require precise stereochemical control in their synthetic routes.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, crucial for producing chiral alcohols and amines in pharmaceutical synthesis.
• Asymmetric C-C Bond Formation: Catalyzes key cross-coupling and addition reactions, such as asymmetric allylic alkylation, to construct complex chiral molecular frameworks.
• Pharmaceutical Intermediate Synthesis: Used in the development and scale-up of active pharmaceutical ingredients (APIs) where high enantiomeric excess (ee) is mandated.
• Agrochemical Production: Enables the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Manufacturing: Applied in the production of specialty flavors, fragrances, and advanced electronic materials requiring specific chirality.
• Academic & Industrial Research: A valuable tool for methodology development in organic synthesis and catalysis research.

Basic Information

Product Name	(S)-(-)-[(S)-2-Di(3,5-Xylyl)Phosphinoferrocenyl][2-Di(3,5-Xylyl)Phosphinophenyl]Methanol
CAS No.	851308-45-7
Molecular Formula	C51H48FeO2P2
Molecular Weight	786.70 g/mol
Synonyms	(S,S)-JOSIPHOS SL-J009-1; (S)-(-)-[1-[(S)-2-(Bis(3,5-dimethylphenyl)phosphino)ferrocenyl]ethyl]bis(3,5-dimethylphenyl)phosphine methanol adduct; JOSIPHOS SL-J009-1; (S,S)-JOSIPHOS ligand; (S)-1-[(R)-2-(Bis(3,5-xylyl)phosphino)ferrocenyl]ethylbis(3,5-xylyl)phosphine methanol adduct; Chiral Ferrocenyl Phosphine Ligand; SL-J009-1; (S,S)-Fe-Phox Methanol Adduct
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands undergoes rigorous analytical testing to ensure exceptional purity and enantiomeric integrity, which are critical for reproducible catalytic performance. Our standard quality commitment includes comprehensive analysis via HPLC, NMR (¹H, ³¹P), and chiral analysis to confirm identity, purity, and enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications. We adhere to stringent in-house quality standards suitable for GMP-intermediate and advanced R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent oxidation. For long-term storage, keep the container in a freezer at -20°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
¹H NMR	Conforms
³¹P NMR	Conforms
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.