Description

(S)-1-{(R)-2-[Di(1-Naphthyl)Phosphino]Ferrocenyl}Ethyldi(3,5-Xylyl)Phosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to impart exceptional enantioselectivity and catalytic activity in a range of transition-metal-catalyzed reactions, enabling the efficient synthesis of single-enantiomer compounds. This ligand is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for creating advanced intermediates and active ingredients.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, critical for producing chiral alcohols and amines in pharmaceutical synthesis.
• Asymmetric Cross-Coupling Reactions: Facilitates C-C and C-X bond-forming reactions with high stereocontrol, such as Suzuki-Miyaura and Buchwald-Hartwig aminations.
• Asymmetric Allylic Substitution: Used in Tsuji-Trost and related reactions to construct chiral centers with high regio- and enantioselectivity.
• Catalyst Screening Libraries: A key component in high-throughput screening for the discovery and optimization of new asymmetric catalytic processes.
• Academic & Industrial R&D: Fundamental research tool in organometallic chemistry and process development for scale-up of chiral molecules.
• Synthesis of Chiral Auxiliaries & Ligands: Serves as a sophisticated building block for developing next-generation chiral catalysts and reagents.

Basic Information

Product Name	(S)-1-{(R)-2-[Di(1-Naphthyl)Phosphino]Ferrocenyl}Ethyldi(3,5-Xylyl)Phosphine
CAS No.	851308-41-3
Molecular Formula	C57H48FeP2
Molecular Weight	850.77 g/mol
Synonyms	(S,R)-Josiphos SL-J009-1; (S)-1-[(R)-2-(Bis(1-naphthyl)phosphino)ferrocenyl]ethyldi(3,5-xylyl)phosphine; Josiphos ligand SL-J009-1; (S)-1-((R)-2-(Di(1-naphthalenyl)phosphino)ferrocenyl)ethyldi(3,5-dimethylphenyl)phosphine; SL-J009-1; (S,R)-Josiphos; Chiral Ferrocenyl Diphosphine Ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and tested under strict inert atmosphere conditions to prevent oxidation and ensure maximum catalytic performance. We guarantee high chemical purity and chiral integrity, verified by advanced analytical techniques including HPLC, NMR (¹H, ³¹P), and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and full spectroscopic data is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
³¹P NMR	Conforms to reference spectrum
Solubility	Soluble in common organic solvents (Toluene, DCM, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.