Description

(R)-1-{(S)-2-[Di(1-Naphthyl)Phosphino]Ferrocenyl}Ethyldi(3,5-Xylyl)Phosphine CAS NO 851308-40-2 is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in advanced asymmetric catalysis. Its value lies in providing exceptional enantioselectivity and catalytic activity for the synthesis of complex, single-enantiomer molecules. This ligand is essential for research and production in the pharmaceutical and fine chemical industries, where precise stereochemical control is paramount for developing active pharmaceutical ingredients (APIs) and high-value intermediates.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, critical for producing chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Enables the efficient, stereocontrolled construction of complex API scaffolds, including those for cardiovascular, neurological, and oncological therapeutics.
• Asymmetric Cross-Coupling Reactions: Facilitates C-C and C-X bond-forming reactions with high enantiomeric excess, valuable for creating novel molecular architectures.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A vital tool for methodology development in organic synthesis and process chemistry within university and corporate laboratories.
• Fine Chemical Manufacturing: Applied in the synthesis of specialty chemicals, flavors, fragrances, and advanced materials requiring specific chirality.

Basic Information

Product Name	(R)-1-{(S)-2-[Di(1-Naphthyl)Phosphino]Ferrocenyl}Ethyldi(3,5-Xylyl)Phosphine
CAS No.	851308-40-2
Molecular Formula	C57H48FeP2
Molecular Weight	850.77 g/mol
Synonyms	(R)-(S)-Josiphos SL-J009-1; (R)-1-[(S)-2-(Bis(1-naphthyl)phosphino)ferrocenyl]ethyldi(3,5-xylyl)phosphine; Josiphos Ligand SL-J009-1; (R)-1-[(S)-2-(Di-1-naphthylphosphino)ferrocenyl]ethyldi(3,5-dimethylphenyl)phosphine; (R)-1-[(S)-2-[Bis(1-naphthalenyl)phosphino]ferrocenyl]ethyldi(3,5-dimethylphenyl)phosphine; SL-J009-1; Ferrocenyl Josiphos Ligand; Chiral Ferrocenyl Diphosphine Ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and tested under strict quality management protocols to ensure exceptional purity and performance consistency for catalytic applications. We provide comprehensive Certificates of Analysis (COA) detailing critical parameters such as chiral purity (enantiomeric excess), chemical purity, and identity confirmation. Our quality systems support development and cGMP manufacturing needs for the pharmaceutical sector.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Keep the container tightly sealed in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% e.e.
Solubility	Soluble in common organic solvents (Toluene, DCM, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.