Description

(R)-Gna-T Phosphoramidite is a high-purity, chiral phosphoramidite monomer, a critical building block in automated oligonucleotide synthesis. Its value lies in enabling the precise, large-scale production of stereodefined nucleic acid analogs, which are essential for advanced therapeutic and diagnostic applications. This product is primarily needed by biotechnology and pharmaceutical companies engaged in the development of antisense oligonucleotides, siRNA, and other next-generation nucleic acid-based drugs, where sequence fidelity and chiral purity are paramount.

Application

• Synthesis of Stereocontrolled Oligonucleotides: Key monomer for the solid-phase synthesis of RNA and DNA analogs with defined chirality at the phosphorous center.
• Antisense Oligonucleotide (ASO) Development: Used in creating therapeutic ASOs for targeted gene silencing in rare diseases and oncology.
• Small Interfering RNA (siRNA) Production: Essential for manufacturing siRNA duplexes used in RNA interference (RNAi) therapeutics.
• Diagnostic Probe Fabrication: Enables the production of high-specificity labeled probes for genomic testing and molecular diagnostics.
• Research & Development: Serves as a vital reagent in academic and industrial labs exploring novel nucleic acid chemistries and mechanisms.
• Phosphorothioate Backbone Modification: A precursor in the synthesis of nuclease-resistant oligonucleotide backbones for enhanced in vivo stability.

Basic Information

Product Name	(R)-Gna-T Phosphoramidite
CAS No.	851050-23-2
Molecular Formula	C41H49N6O7P
Molecular Weight	768.85 g/mol
Synonyms	1-[(2R,4S,5R)-5-[Bis(4-methoxyphenyl)(phenyl)methoxy]methyl-4-[(2-cyanoethoxy)(diisopropylamino)phosphanyl]oxy-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione; Guanosine Phosphoramidite, (R)-isomer; DMT-G(iBu) Phosphoramidite (R); (R)-2'-Deoxy-2'-fluoro-guanosine Phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-guanosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Gna-T Phosphoramidite; RNA Phosphoramidite Monomer
EINECS	Contact for details

Quality Control

Every batch of (R)-Gna-T Phosphoramidite is manufactured and tested under strict quality systems to ensure it meets the exacting standards required for oligonucleotide synthesis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, chiral integrity, and critical impurity profiles. Our quality commitment aligns with GMP principles for advanced therapeutic starting materials, ensuring traceability, consistency, and reliability for your critical development and cGMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term stability, keep the desiccant in the original packaging.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (R-isomer)
Water Content (KF)	≤ 0.5%
Solubility	Clear, colorless solution in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.