Description

2-(tert-Butoxycarbonylamino)-3-(2,6-Difluorophenyl)Propanoic Acid is a high-purity, protected amino acid derivative that serves as a critical building block in advanced organic synthesis. Its primary value lies in enabling the controlled construction of complex peptide and small molecule structures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system and oncological pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in peptidomimetic and small molecule drug discovery programs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a protected, fluorinated phenylalanine analog into peptide chains.
• Protease Inhibitor Development: Serves as a core structural element in the design and synthesis of protease enzyme inhibitors due to its difluorophenyl moiety.
• Chemical Biology Research: Employed in the preparation of labeled probes, activity-based protein profiling (ABPP) reagents, and other tools for studying biological mechanisms.
• Agrochemical Intermediate: Potential use in the synthesis of advanced, fluorinated active ingredients for crop protection products.
• Material Science Precursor: Can be utilized in the development of specialized polymers and advanced materials requiring fluorinated aromatic components.

Basic Information

Product Name	2-(tert-Butoxycarbonylamino)-3-(2,6-Difluorophenyl)Propanoic Acid
CAS No.	851047-82-0
Molecular Formula	C14H17F2NO4
Molecular Weight	301.29 g/mol
Synonyms	Boc-2,6-Difluoro-DL-phenylalanine; N-(tert-Butoxycarbonyl)-3-(2,6-difluorophenyl)-DL-alanine; 2-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-(2,6-difluorophenyl)propanoic acid; Boc-2,6-Dif-Phe-OH; N-Boc-2,6-difluorophenylalanine; 3-(2,6-Difluorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid; (RS)-2-(tert-Butoxycarbonylamino)-3-(2,6-difluorophenyl)propionic acid
EINECS	Contact for details

Quality Control

Our 2-(tert-Butoxycarbonylamino)-3-(2,6-Difluorophenyl)Propanoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.