Description

Maleimide-PEG-Valeric Acid is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a maleimide group and a carboxylic acid, separated by a flexible PEG spacer and a valeric acid linker. This compound is essential for creating stable, site-specific bioconjugates, particularly in the development of antibody-drug conjugates (ADCs) and other therapeutic biologics. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic industries who require precise and controlled coupling of biomolecules such as proteins, peptides, and antibodies.

Application

• Antibody-Drug Conjugate (ADC) Development: Site-specific conjugation of cytotoxic drugs to monoclonal antibodies via cysteine residues.
• Protein-Polymer Conjugation: PEGylation of therapeutic proteins to enhance solubility, stability, and circulation half-life.
• Peptide Labeling & Modification: Introduction of functional handles (e.g., for further coupling or fluorescent labeling) onto peptides.
• Surface Functionalization: Immobilization of biomolecules onto sensor chips, nanoparticles, or other solid supports for diagnostic assays.
• Crosslinking Agent: For creating defined protein-protein or protein-small molecule complexes in structural biology studies.
• Hydrogel Formation: As a crosslinker in the synthesis of biocompatible hydrogels for drug delivery and tissue engineering.

Basic Information

Product Name	Maleimide-PEG-Valeric Acid
CAS No.	851040-94-3
Molecular Formula	CnH2n+1OmN (Variable based on PEG chain length 'n')
Molecular Weight	Variable (Depends on PEG chain length; e.g., ~1000 Da, ~2000 Da, ~5000 Da)
Synonyms	Mal-PEGn-VA; Maleimide-Polyethylene glycol-Valeric Acid; Valeric Acid-PEG-Maleimide; 5-[(3-{2-[2-(2-{3-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methoxy]propoxy}ethoxy)ethoxy]propoxy}carbonyl)pentanoic Acid (for specific PEG length); mPEG-Mal; NHS-PEG-Maleimide derivative; Heterobifunctional PEG crosslinker
EINECS	Contact for details

Quality Control

Our Maleimide-PEG-Valeric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and functional group quantification, NMR for structural confirmation, and MS for molecular weight verification. Certificates of Analysis (COA) detailing purity, substitution ratio, and solvent content are provided to ensure compliance with research and cGMP-grade standards for critical bioconjugation applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, store under inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Maleimide Substitution	≥ 90%
Average Molecular Weight	As specified (e.g., 1000, 2000, 5000 Da)
Polydispersity Index (PDI)	≤ 1.05
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.