Description

(2S,4S)-5-Benzyloxycarbonylamino-2-tert-Butoxycarbonylamino-4-Triisopropylsilanyloxy-Pentanoic Acid is a sophisticated, orthogonally protected amino acid derivative essential for advanced peptide synthesis. Its core value lies in enabling the precise, sequential construction of complex peptides by providing selective deprotection points for the amino and hydroxyl functionalities. This compound is critically needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and bioactive molecules. The specific stereochemistry ensures the correct three-dimensional structure of the final synthetic target.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled, stepwise assembly of peptides on resin supports.
• Solution-Phase Peptide Synthesis: Used in classical coupling strategies for synthesizing peptide fragments in solution.
• Pharmaceutical Intermediate: Serves as a critical precursor in the research and development of peptide-based active pharmaceutical ingredients (APIs).
• Peptidomimetic Drug Design: Facilitates the creation of modified peptide structures with enhanced stability, bioavailability, or receptor affinity.
• Bioconjugation and Labeling: The protected functional groups allow for selective modification, useful in creating peptide-drug conjugates or diagnostic probes.
• Academic and Industrial R&D: A valuable tool for chemists studying peptide structure-activity relationships and developing new synthetic methodologies.

Basic Information

Item	Detail
Product Name	(2S,4S)-5-Benzyloxycarbonylamino-2-tert-Butoxycarbonylamino-4-Triisopropylsilanyloxy-Pentanoic Acid
CAS No.	850996-85-9
Molecular Formula	C30H52N2O7Si
Molecular Weight	580.83 g/mol
Synonyms	(2S,4S)-5-[(Benzyloxy)carbonyl]amino-2-[(tert-butoxy)carbonyl]amino-4-[(triisopropylsilyl)oxy]pentanoic acid; Fmoc-Thr(tBu)-OH (related protected form); Z-4-TIPSoxy-L-threonine(Boc)-OH; Boc-L-Thr(TIPS)-Z-OH; Protected L-Threonine derivative; CAS 850996-85-9; Peptide synthesis building block
EINECS	Contact for details

Quality Control

Every batch of (2S,4S)-5-Benzyloxycarbonylamino-2-tert-Butoxycarbonylamino-4-Triisopropylsilanyloxy-Pentanoic Acid is produced under strict quality management protocols to ensure the high purity and stereochemical integrity required for sensitive synthetic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.