Description

(2S,4R)-5-Benzyloxycarbonylamino-2-tert-Butoxycarbonylamino-4-Triisopropylsilanyloxy-Pentanoic Acid is a sophisticated, multi-protected amino acid derivative that serves as a critical building block in advanced organic synthesis. Its value lies in providing precise stereochemical control and orthogonal protecting groups, enabling the efficient construction of complex peptides and peptidomimetics. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel therapeutic agents and conducting structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: Key building block for the solid-phase and solution-phase synthesis of complex peptide-based drugs and bioactive compounds.
• Peptidomimetic Research: Used in the design and synthesis of peptidomimetics to improve metabolic stability and bioavailability of drug candidates.
• Protected Amino Acid Derivative: Provides orthogonal protection (Cbz, Boc, TIPS) for selective deprotection in multi-step synthetic sequences.
• Stereoselective Synthesis: The defined (2S,4R) stereochemistry is crucial for constructing peptides with specific three-dimensional conformations and biological activity.
• API Development: Intermediate in the research and development of new Active Pharmaceutical Ingredients (APIs), especially for oncological and metabolic diseases.
• Chemical Biology Probes: Synthesis of labeled or modified peptides used as tools for studying biological pathways and protein interactions.

Basic Information

Product Name	(2S,4R)-5-Benzyloxycarbonylamino-2-tert-Butoxycarbonylamino-4-Triisopropylsilanyloxy-Pentanoic Acid
CAS No.	850996-84-8
Molecular Formula	C30H52N2O7Si
Molecular Weight	580.83 g/mol
Synonyms	(2S,4R)-5-[(Benzyloxy)carbonyl]amino-2-[(tert-butoxy)carbonyl]amino-4-[(triisopropylsilyl)oxy]pentanoic Acid; Fmoc-Dap(TIPS)-OH (related protected form); Boc-Dap(TIPS)-OH (related protected form); (2S,4R)-2-[(tert-Butoxycarbonyl)amino]-4-[(triisopropylsilyl)oxy]-5-[(phenylmethoxy)carbonyl]aminopentanoic Acid; Nα-Boc-Nε-Cbz-L-2,4-diaminobutyric acid 4-O-TIPS derivative; Protected L-Dab derivative; CAS 850996-84-8
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry to confirm identity, stereochemical purity, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, supporting your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.