Description

Etoricoxib-D3 is a deuterium-labeled analog of the selective COX-2 inhibitor etoricoxib, specifically designed for use as an internal standard in quantitative bioanalytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in pharmacokinetic and metabolic studies, providing superior precision over non-labeled standards. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug development and regulatory compliance.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the precise measurement of etoricoxib in biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of etoricoxib, correcting for matrix effects and instrument variability.
• Bioequivalence and Clinical Trials: Supports robust analytical method development and validation for bioequivalence studies and clinical trial sample analysis, ensuring data integrity for regulatory submissions.
• Forensic and Anti-Doping Analysis: Enables accurate quantification in specialized testing environments where precise measurement of drug concentrations is legally or competitively mandated.
• Pharmaceutical Quality Control: Can be utilized in advanced impurity profiling and method development for the analysis of etoricoxib in active pharmaceutical ingredient (API) and finished dosage forms.

Basic Information

Product Name	Etoricoxib-D3
CAS No.	850896-71-8
Molecular Formula	C18H12D3ClN2O2S
Molecular Weight	361.86 g/mol
Synonyms	5-Chloro-2-(6-methylpyridin-3-yl)-3-(4-(methyl-d3)sulfonyl)phenyl]pyridine; 5-Chloro-6'-methyl-3-[4-(methyl-d3)sulfonyl]phenyl]-2,3'-bipyridine; Etoricoxib (methyl-d3); Deuterated Etoricoxib; Etoricoxib Internal Standard; Arcoxia-D3; MK-0663-D3
EINECS	Contact for details

Quality Control

Our Etoricoxib-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity by HPLC, and confirmation of structure. We adhere to relevant industry standards for stable isotope-labeled compounds, ensuring reliable performance as an internal standard. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.